Regarding the Workshop Framework Override, I can confirm that I have it installed and active, and do not experience any CTD's in the main menu or in game play as a result of it. If you are getting CTD's with it active, and not when it is disabled, something in your load order is almost certainly conflicting with it, but I don't know all of the mods in your load order, so I don't know what might be causing it. In particular, I'm not sure why you would be getting crashes in the main menu, not many mods should be active at that point.
To confirm, you mention disabling mods - I am hoping that when you do that you are starting a new playthrough, or at least rolling back to a save before those mods were added? FO4 breaks if you try to play a save without mods that were once part of that save. You probably know that, no offence intended; as I said, I just want to confirm.
I recommend installing
Buffout 4 and the
Crash Log Scanner next. Once you get them working, Buffout 4 will help reduce crashes, and generate logs to help you identify what is causing the crashes you still get. The Scanner will help you interpret the logs.
You also might try posting in the SS2 Questions and Help forum, since it gets a bit more traffic, and someone there might recognize an issue in your load order that I am missing.