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IIRC, the v-sync checkbox in the vanilla launcher does nothing. You need to edit Fallout 4.ini to adjust the frame rate. (can't remember the setting name) I don't know about AMD, but many have reported that using nVidia's adaptable v-sync feature helps smooth out some of the game's stuttering. Google will be your friend here. I know I have read several reddit posts on this over the years.
You may find some useful information in the posts here: