It's kinda hard to say tbh without more information as to what other kinds of mods you're using; I tend to run with 200-300 mods per playthrough myself (oops). Have had playthroughs that were ground to a halt, but that usually has more to do with me losing interest (Chapter 3 is... not my favorite ^^). Have gotten to the end at least 2-3 times. I tend to play on easy, have picked multiple different factions, I don't use custom companions, and always help Preston and build up Sanctuary. XD
I know using item sorters that tag quests can mess things up, and as Sim Settlements 2 is very script heavy, probably don't want to use a lot of other script heavy mods. Honestly, my suggestion would be try a stripped-down load order so you can focus on SS2 and its story.